RESUMEN
Dep'ts and Agencies (Jan. 05, 2021), https://www.whitehouse.gov/wp-content/uploads/2021/01 /M-21-11.pdf 226 Novel Coronavirus (COVID-19), USAID (Mar. 21, 2020), https:/ www.usaid.gov/coronavirus [http://web.archive.org /web/20200321032153] 217 U.S. Gov't Accountability Off., GAO-12-331G, Government Auditing Standards (2018) 218 OTHER AUTHORITIES Advice on the Use of Masks in the Community, During Home Care, and in Health Care Settings in the Context of COVID-19, WHO (Mar. 19, 2020), https://apps.who.int/iris/bitstream/handle/10665/331493 /WHO-2019-nCoV-IPC_Masks-2020.2-eng.pdf?sequence= 14&isAllowed=y 218 Amindeh Blaise Atabong, In Cameroon, Face Masks Are Compulsory-But Unaffordable for Many, Mail & Guardian (Apr. 18, 2020), https:// mg.co.za/article/2020-04-18-in-cameroon-face-masks-are -compulsory-but-unaffordable-for-many 217, 218 Cost of Living in Yaounde, Numbeo, https://www.numbeo.com/cost -of-living/in/Yaounde-Cameroon (last visited Mar. 5, 2021) 218 Fadela Chaib, Shortage of Personal Protective Equipment Endangering Health Workers Worldwide, WHO (Mar. 02, 2020), https://www .who.int/news/item/03-03-2020-shortage-of-personal-protective -equipment-endangering-health-workers-worldwide 217 How COVID-19 Spreads, CDC (last updated Oct. 28, 2020), https:// www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/how -COVID-spreads.html. 216 How Much Water Do You Use at Home?, U.S. Geological Surv. (last visited Mar. 5, 2021), https://water.usgs.gov/edu/activity -percapita.php 218 Scott S. Sheffler, A Reasoned Case for a "Grant Disputes Act," 47 Pub. L.J. 209 (2018) 207 STATEMENT OF RELATED CASES Pursuant to Rule 47.5 of the Federal Circuit Rules of Practice, Democracy Worldwide is unaware of another appeal in or from the same civil action or proceeding in the lower court or body that was previously before this Court or another appellate court. In November 2019, the Center of Excellence on Democracy, Human Rights, and Governance, which is part of the United States Agency for International Development (USAID), published a Notice of Funding Opportunity (NOFO), announcing that USAID had $8,000,000 for human rights programming awards to increase protection for human rights defenders in Central Africa. Democracy Worldwide proposed a program to support human rights defenders in Cameroon by strengthening the normative frameworks and institutional architecture that would help Cameroon respect its human rights obligations and by building the capacity of civil society actors to promote those rights, monitor compliance, and demand accountability.
RESUMEN
We modeled 3D structures of all SARS-CoV-2 proteins, generating 2,060 models that span 69% of the viral proteome and provide details not available elsewhere. We found that Ë6% of the proteome mimicked human proteins, while Ë7% was implicated in hijacking mechanisms that reverse post-translational modifications, block host translation, and disable host defenses; a further Ë29% self-assembled into heteromeric states that provided insight into how the viral replication and translation complex forms. To make these 3D models more accessible, we devised a structural coverage map, a novel visualization method to show what is-and is not-known about the 3D structure of the viral proteome. We integrated the coverage map into an accompanying online resource (https://aquaria.ws/covid) that can be used to find and explore models corresponding to the 79 structural states identified in this work. The resulting Aquaria-COVID resource helps scientists use emerging structural data to understand the mechanisms underlying coronavirus infection and draws attention to the 31% of the viral proteome that remains structurally unknown or dark.